Tag/Conjugate
Unconjugated
Antigen Description
This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Function
poly(A) RNA binding; protein binding; ubiquitin protein ligase binding
Synonyms
SUMO2; small ubiquitin-like modifier 2; HSMT3; SMT3B; SUMO3; Smt3A; SMT3H2; small ubiquitin-related modifier 2; sentrin 2; SMT3 homolog 2; ubiquitin-like protein SMT3A; ubiquitin-like protein SMT3B; SMT3 suppressor of mif two 3 homolog 2
Citations
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Strong, ER; Schimenti, JC; et al. Evidence Implicating CCNB1IP1, a RING Domain-Containing Protein Required for Meiotic Crossing Over in Mice, as an E3 SUMO Ligase. GENES 1:440-451(2010).
Becker, J; Barysch, SV; et al. Detecting endogenous SUMO targets in mammalian cells and tissues. NATURE STRUCTURAL & MOLECULAR BIOLOGY 20:525-+(2013).
COA
Certificate of Analysis
