Anti-SIRT1 (N-terminal) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

SIRT1 antibody was raised against a 19 amino acid peptide near the amino terminus of human SIRT1.

Conjugate

Alternative Names

SIRT1; sirtuin 1; SIR2L1; NAD-dependent protein deacetylase sirtuin-1; hSIR2; hSIRT1; SIR2alpha; sir2-like 1; sirtuin type 1; SIR2-like protein 1; regulatory protein SIR2 homolog 1; NAD-dependent deacetylase sirtuin-1

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]

Pathway

AMPK signaling pathway; Amphetamine addiction; Androgen receptor signaling pathway; Cellular response to heat stress; Cellular responses to stress; E2F transcription factor network; Energy Metabolism; Epigenetic regulation of gene expression