Human SIRT1 blocking peptide (CDBP2680)

Synthetic Human SIRT1 blocking peptide for Apuri, BL, ELISA

Product Overview
Blocking/Immunizing peptide for anti-SIRT1 antibody
Target
SIRT1
Nature
Synthetic
Species Reactivity
Human, Mouse, Dog, Rat
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.
Procedure
None
Format
Lyophilized powder
Size
100 μg
Preservative
None
Storage
Shipped at ambient temperature, store at -20°C.
UniProt ID
Antigen Description
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Function
HLH domain binding; NOT NAD+ ADP-ribosyltransferase activity; NAD+ binding; NAD-dependent histone deacetylase activity; NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent protein deacetylase activity; NAD-dependent protein deacetyl
Synonyms
SIRT1; sirtuin 1; sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) , sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 1; NAD-dependent deacetylase sirtuin-1; SIR2L1; hSIR2; hSIRT1; SIR2alpha; sir2-like 1; sirtuin type 1; SIR2-like protein 1;

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References


Shimazu, T; Horinouchi, S; et al. Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3 '-end processing. JOURNAL OF BIOLOGICAL CHEMISTRY 282:4470-4478(2007).
Morita, S; Furukawa, S; et al. Expression of antigens related to hypoxia, stress, and apoptosis in the myocardium after fatal carbon monoxide exposure. ROMANIAN JOURNAL OF LEGAL MEDICINE 21:253-258(2013).

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