SIRT1 blocking peptide (CDBP6119)

Nature
Synthetic
Immunogen
19 amino acids near the amino terminus of human SIRT1.
Species Reactivity
Rat, human, mouse
Tag/Conjugate
Unconjugated
Procedure
None
Format
Liquid
Concentration
200 μg/mL
Size
0.05mg
Preservative
None
Storage
-20°C
UniProt ID
Antigen Description
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Function
HLH domain binding; NOT NAD+ ADP-ribosyltransferase activity; NAD+ binding; NAD-dependent histone deacetylase activity; NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent protein deacetylase activity; NAD-dependent protein deacetylase activity; bHLH transcription factor binding; deacetylase activity; enzyme binding; histone binding; histone deacetylase activity; identical protein binding; keratin filament binding; metal ion binding; mitogen-activated protein kinase binding; p53 binding; protein C-terminus binding; protein binding; protein deacetylase activity; transcription corepressor activity; transcription corepressor activity; transcription factor binding
Synonyms
SIRT1; sirtuin 1; SIR2L1; NAD-dependent protein deacetylase sirtuin-1; hSIR2; hSIRT1; SIR2alpha; sir2-like 1; sirtuin type 1; SIR2-like protein 1; regulatory protein SIR2 homolog 1; NAD-dependent deacetylase sirtuin-1

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References


Koyuncu, E; Budayeva, HG; et al. Sirtuins Are Evolutionarily Conserved Viral Restriction Factors. MBIO 5:-(2014).
Hu, N; Long, H; et al. Aberrant expression pattern of histone acetylation modifiers and mitigation of lupus by SIRT1-siRNA in MRL/lpr mice. SCANDINAVIAN JOURNAL OF RHEUMATOLOGY 38:464-471(2009).

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