SIRT1 blocking peptide (DAG-P1166)

Specificity
Widely expressed.
Nature
Synthetic
Tag/Conjugate
Unconjugated
Sequence Similarities
Belongs to the sirtuin family. Class I subfamily.Contains 1 deacetylase sirtuin-type domain.
Cellular Localization
Cytoplasm. Mitochondrion and Nucleus > PML body. Cytoplasm. Recruited to the nuclear bodies via its interaction with PML. Colocalized with APEX1 in the nucleus. May be found in nucleolus, nuclear euchromatin, heterochromatin and inner membrane. Shuttle
Procedure
None
Format
Liquid
Buffer
Information available upon request.
Preservative
None
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.
UniProt ID
Antigen Description
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Function
HLH domain binding; NOT NAD+ ADP-ribosyltransferase activity; NAD+ binding; NAD-dependent histone deacetylase activity; NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent protein deacetylase activity; NAD-dependent protein deacetyl
Synonyms
SIRT1; sirtuin 1; SIR2L1; NAD-dependent protein deacetylase sirtuin-1; hSIR2; hSIRT1; SIR2alpha; sir2-like 1; sirtuin type 1; SIR2-like protein 1; regulatory protein SIR2 homolog 1; NAD-dependent deacetylase sirtuin-1;

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References


Caruso, R; Marafini, I; et al. Defective expression of SIRT1 contributes to sustain inflammatory pathways in the gut. MUCOSAL IMMUNOLOGY 7:1467-1479(2014).
Wang, RH; Li, CL; et al. Liver Steatosis and Increased ChREBP Expression in Mice Carrying a Liver Specific SIRT1 Null Mutation under a Normal Feeding Condition. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 6:682-690(2010).

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