Specifications
Immunogen
Synthetic peptide conjugated to KLH derived from within residues 50 - 150 of Human Scavenging Receptor SR-BI.
Applications
Application Notes
WB: 1 μg/ml.
Target
Alternative Names
SCARB1; scavenger receptor class B, member 1; CLA1; SRB1; CLA-1; SR-BI; CD36L1; HDLQTL6; scavenger receptor class B member 1; CD36 and LIMPII analogous 1; scavenger receptor class B type III; CD36 antigen (collagen type I receptor, thrombospondin receptor
Product Background
Antigen Description
Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester.
Pathway
Bile secretion; Binding and Uptake of Ligands by Scavenger Receptors; Fat digestion and absorption; HDL-mediated lipid transport
Citations
Publication ()
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COA
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