Anti-SCARB1 monoclonal antibody, clone 2G4

Antibody Isotype

IgG1

Clone

2G4

Species Reactivity

Human

Immunogen

Recombinant full length protein corresponding to Human Scavenging Receptor SR-BI aa 1-509. Isoform 1.Sequence: MGCSAKARWA AGALGVAGLL CAVLGAVMIV MVPSLIKQQV LKNVRIDPSS LSFNMWKEIP IPFYLSVYFF DVMNPSEILK GEKPQVRERG PYVYREFRHK SNITFNNNDT VSFLEYRTFQ FQPSKSHGSE S

Conjugate

Application Notes

WB: 1/4000;

Alternative Names

SCARB1; scavenger receptor class B, member 1; CD36 antigen (collagen type I receptor, thrombospondin receptor) like 1 , CD36L1; scavenger receptor class B member 1; CLA 1; CLA1; SR BI; SRB1; CD36 and LIMPII analogous 1; scavenger receptor class B type III

Entrez Gene ID

UniProt ID

Antigen Description

Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester.

Pathway

Bile secretion, organism-specific biosystem; Bile secretion, conserved biosystem; Fat digestion and absorption, organism-specific biosystem; Fat digestion and absorption, conserved biosystem; Folate Metabolism, organism-specific biosystem; HDL-mediated lipid transport, organism-specific biosystem; Hepatitis C, organism-specific biosystem;