Anti-RIT1 monoclonal antibody, clone 25H8

Antibody Isotype

IgG1

Clone

25H8

Species Reactivity

Mouse; Human

Immunogen

Hybridoma produced by the fusion of splenocytes from mice immunized with recombinant full length human Rit protein and mouse myeloma cells.

Conjugate

Application Notes

WB: 0.5 - 1 μg/ml;

Alternative Names

RIT1; Ras-like without CAAX 1; Ric (Drosophila) like, expressed in many tissues , RIT; GTP-binding protein Rit1; GTP binding protein Roc1; MGC125864; MGC125865; RIBB; Ric like; expressed in many tissues; ROC1; GTP-binding protein Roc1; ras-like without CA

Entrez Gene ID

UniProt ID

Antigen Description

Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation.

Pathway

NGF signalling via TRKA from the plasma membrane, organism-specific biosystem; Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signalling by NGF, organism-specific biosystem; Signalling to ERKs, organism-specific biosystem; Signalling to p38 via RIT and RIN, organism-specific biosystem; Trk receptor signaling mediated by the MAPK pathway, organism-specific biosystem;