Anti-Parathyroid Hormone Receptor 1 monoclonal antibody (DMABT-Z59892)

Mouse anti-Opossum Parathyroid Hormone Receptor 1 monoclonal antibody for WB, ICC, IF, IP Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
QM3
Species Reactivity
Opossum
Immunogen
Synthetic peptide: RSAKTKKEKPAEKLYSQ, corresponding to amino acids 71/87 of Opossum kidney Parathyroid Hormone Receptor 1 RSAKTKKEKPAEKLYSQ Run BLAST with Run BLAST with
Conjugate
Unconjugated

Target


Alternative Names
MGC138426; MGC138452; Parathyroid hormone 1 receptor; Parathyroid hormone/parathyroid hormone related peptide receptor; Parathyroid hormone/parathyroid hormone related protein receptor; Parathyroid hormone/parathyroid hormone-related peptide receptor

Product Background


Gene summary
PTH1R (Parathyroid Hormone 1 Receptor) is a Protein Coding gene. Diseases associated with PTH1R include chondrodysplasia, blomstrand type and metaphyseal chondrodysplasia, murk jansen type. Among its related pathways are Signaling by GPCR and Endochondral Ossification. GO annotations related to this gene include G-protein coupled receptor activity and protein self-association. An important paralog of this gene is MGC57346-CRHR1. The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene.
Antigen Description
Chondrodysplasia Blomstrand type (BOCD) [MIM:215045]: Severe skeletal dysplasia. Note=The disease is caused by mutations affecting the gene represented in this entry. Eiken skeletal dysplasia (EISD) [MIM:600002]: A rare skeletal dysplasia characterized by severely retarded ossification, principally of the epiphyses, pelvis, hands and feet, as well as by abnormal modeling of the bones in hands and feet, abnormal persistence of cartilage in the pelvis and mild growth retardation. Enchondromatosis multiple (ENCHOM) [MIM:166000]: A condition characterized by multiple formation of enchondromas, benign neoplasms derived from mesodermal cells that form cartilage. Enchondromas remain within the substance of a cartilage or bone. Parathyroid hormone/parathyroid hormone-related peptide receptor also known as parathyroid hormone 1 receptor (PTH1R) is a protein that in humans is encoded by the PTH1R gene. PTH1R functions as a receptor for parathyroid hormone (PTH) and for parathyroid hormone-related protein (PTHrP), also called parathyroid hormone-like hormone (PTHLH). This "classical" PTH receptor is expressed in high levels in bone and kidney and regulates calcium ion homeostasis through activation of adenylate cyclase and phospholipase C. In bone, it is expressed on the surface of osteoblasts. When the receptor is activated through PTH binding, osteoblasts express RANKL (Receptor Activator of Nuclear Factor kB Ligand), which binds to RANK (Receptor Activator of Nuclear Factor kB) on osteoclasts. This turns on osteoclasts to ultimately increase the resorption rate. This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide.

Citations


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References


Azevedo-Neto, RD; Gonzaga, CC; et al. Fragmented Adipose Tissue Transplanted to Craniofacial Deformities Induces Bone Repair Associated With Immunoexpression of Adiponectin and Parathyroid Hormone 1-Receptor. CLEFT PALATE-CRANIOFACIAL JOURNAL 50:639-647(2013).
Guo, J; Song, LG; et al. Fluorescent ligand-directed co-localization of the parathyroid hormone 1 receptor with the brush-border scaffold complex of the proximal tubule reveals hormone-dependent changes in ezrin immunoreactivity consistent with inactivation. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1823:2243-2253(2012).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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