This product (Catalog No. DPABH-03727) is a rabbit-derived polyclonal antibody raised against human PPY. This antibody exhibits cross-reactivity with PPY from rat. It has been affinity purified by Protein A. This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded 95 aa preproprotein is synthesized in the pancreatic islets of Langerhans and proteolytically processed to generate two peptide products. These products include the active pancreatic hormone of 36 aa and an icosapeptide of unknown function. This hormone acts as a regulator of pancreatic and gastrointestinal functions and may be important in the regulation of food intake. Plasma level of this hormone has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa. In addition, infusion of this hormone in obese rodents has shown to decrease weight gain. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. DPABH-03727 is suitable for use in Western blot (WB) (1:1,000–1:5,000) application. DPABH-03727 is supplied as a liquid formulation in pH7.4 PBS, 0.05% sodium azide, 40% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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References
Dearomative Cycloadditions Utilizing an Organic Photosensitizer: An Alternative to Iridium Catalysis
A highly efficient, cheap, and organic alternative to the commonly used iridium photosensitizer (Ir[dF(CF3)ppy](2)(dtbpy))PF6([Ir-F]) is presented for visible-light energy transfer catalysis. The organic dye 2CzPN surpasses [Ir-F] in selectivity while at the same time being easily accessible in one step. The catalyst is recyclable and, due to its uncharged nature, soluble in nonpolar solvents such as toluene. Furthermore, the scope of molecular scaffolds that are compatible substrates for visible-light catalyzed dearomative cycloadditions is expanded.
Synthesis of Alkyl Sulfones from Alkenes and Tosylmethylphosphonium Iodide through Photo-promoted C-C Bond Formation
A new synthetic method for alkyl sulfones through C-C bond formation between alkenes and tosylmethylphosphonium iodide is reported. A tosylmethyl radical is generated from the phosphonium iodide under irradiation of visible light with the aid of fac-Ir(ppy)(3). It undergoes regioselective 1,2-addition across the carbon-carbon double bond to afford an elongated alkyl radical, which abstracts a hydrogen atom from C6F5SH, producing an alkyl sulfone with one-carbon extension.
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