Anti-PPY monoclonal antibody (CABT-36169MH)

Mouse anti-Human PPY monoclonal antibody for ELISA, RIA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
IZC 458-07
Species Reactivity
Human
Immunogen
Pancreatic polypeptide analogue
Conjugate
Unconjugated

Target


Alternative Names
PPY; pancreatic polypeptide; pancreatic prohormone; pancreatic polypeptide Y; PNP; Pancreatic hormone precursor
Entrez Gene ID
UniProt ID

Product Background


Gene summary
PPY (Pancreatic Polypeptide) is a Protein Coding gene. Diseases associated with PPY include obesity and pancreas disease. Among its related pathways are Signaling by GPCR and Metabolism. GO annotations related to this gene include receptor binding and G-protein coupled receptor binding. This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded 95 aa preproprotein is synthesized in the pancreatic islets of Langerhans and proteolytically processed to generate two peptide products. These products include the active pancreatic hormone of 36 aa and an icosapeptide of unknown function. This hormone acts as a regulator of pancreatic and gastrointestinal functions and may be important in the regulation of food intake. Plasma level of this hormone has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa. In addition, infusion of this hormone in obese rodents has shown to decrease weight gain. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Antigen Description
This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions. The physiological role for the icosapeptide has not yet been elucidated. The function about PPY antigen include G-protein coupled receptor binding; hormone activity; receptor binding.
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; Peptide ligand-binding receptors, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by GPCR, organism-specific biosystem.

Citations


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References


Ramanaviciene, A; Ramanavicius, A; et al. Molecularly imprinted polypyrrole-based synthetic receptor for direct detection of bovine leukemia virus glycoproteins. BIOSENSORS & BIOELECTRONICS 20:1076-1082(2004).
ARMSTRONG, CG; MANN, DJ; et al. DROSOPHILA PPY, A NOVEL MALE-SPECIFIC PROTEIN-SERINE THREONINE PHOSPHATASE LOCALIZED IN SOMATIC-CELLS OF THE TESTIS. JOURNAL OF CELL SCIENCE 108:3367-3375(1995).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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