The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq]
Pathway
AMPK inhibits chREBP transcriptional activation activity; AMPK signaling; AMPK signaling pathway; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; Adipocytokine signaling pathway; BDNF signaling pathway; Circadian rhythm; Corticotropin-releasing ho
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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Cheung, PCF; Salt, IP; et al. Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding. BIOCHEMICAL JOURNAL 346:659-669(2000).
Xavier, GD; Leclerc, I; et al. Role of AMP-activated protein kinase in the regulation by glucose of islet beta cell gene expression. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 97:4023-4028(2000).
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