The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The phosphorylated form mediates the interaction between AKT1 and PP2A phosphatase leading to dephosphorylation of AKT1 on the Thr-308 and Ser-373 residues.
Pathway
Activation of Chaperone Genes by XBP1(S); Activation of Chaperones by IRE1alpha; Adaptive Immune System; Beta-catenin phosphorylation cascade; CTLA4 inhibitory signaling; Cell Cycle; Cell Cycle, Mitotic
Citations
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References
Association between CAG repeat length in the PPP2R2B gene and Alzheimer disease in the Japanese population
We analyzed the association between PPP2R2B gene CAG repeat length and Alzheimer disease (AD) susceptibility in the Japanese population. Blood samples were collected from 218 late-onset AD patients and 86 controls. DNA fragments containing the target GAG repeat region were amplified using polymerase chain reaction (PCR). PCR products were sequenced using ABI PRISM 310 genetic analyzer. The mean CAG repeat length did not differ significantly between the control and AD groups. In contrast, the frequency of CAG repeats shorter than 15 was significantly higher in AD group, specifically in the AD with APOE4 subgroup, than in the control group. The results suggest that CAG repeat lengths in the PPP2R2B gene may be potential genetic markers for AD susceptibility in the Japanese population. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
Mapping of the PPP2R2B gene to canine chromosome 2q4.3 by fluorescence in situ hybridization and confirmation by radiation hybrid mapping
COA
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