Specifications
Species Reactivity
Mouse; Rat; Human
Immunogen
Synthetic peptide, corresponding to residues in Human PPP2R2B (UniProt: Q00005).
Applications
Application Notes
WB: 1/1000 - 1/5000; IP: 1/10 - 1/100;
Target
Alternative Names
PPP2R2B; protein phosphatase 2, regulatory subunit B, beta; protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform , protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform , SCA12, spinocerebellar ataxia 12; ser
Product Background
Antigen Description
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity (By similarity). Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance.
Pathway
Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem; Dopaminergic synapse, organism-specific biosystem; Dopaminergic synapse, conserved biosystem; Glycogen Metabolism, organism-specific biosystem; Hepatitis C, organism-specific biosystem; Hepatitis C, conserved biosystem;
Citations
Publication ()
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COA
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