Anti-PPP2R5B polyclonal antibody (DPABH-12253)

Rabbit Anti-Human PPP2R5B (C-terminal) polyclonal antibody for WB

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Mouse, Human
Immunogen
Recombinant fragment (proprietary-tag) within Human PPP2R5B (C terminal). The exact sequence is proprietary.Database link: Q15173
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/1000 - 1/3000.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
PPP2R5B; protein phosphatase 2, regulatory subunit B, beta; protein phosphatase 2, regulatory subunit B (B56), beta isoform; protein phosphatase 2, regulatory subunit B, beta isoform; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta
Entrez Gene ID
UniProt ID

Product Background


Pathway
Activation of Chaperone Genes by XBP1(S); Activation of Chaperones by IRE1alpha; Adaptive Immune System; Beta-catenin phosphorylation cascade; CTLA4 inhibitory signaling; Cell Cycle; Cell Cycle, Mitotic

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


PPP2R2B CAG Repeat Length in the Han Chinese in Taiwan: Association Analyses in Neurological and Psychiatric Disorders and Potential Functional Implications

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Authors: Chen, Chiung-Mei; Hou, Yi-Ting; Liu, Ju-Yun; Wu, Yih-Ru; Lin, Chih-Hsin; Fung, Hon-Chung; Hsu, Wen-Chuin; Hsu, Yuying; Lee, Shen-Hung; Hsieh-Li, Hsiu-Mei; Su, Ming-Tsan; Chen, Shui-Tein; Lane, Hsien-Yuan; Lee-Chen, Guey-Jen

PPP2R2B, a protein widely expressed in neurons throughout the brain, regulates the protein phosphatase 2A (PP2A) activity for the microtubule-associated protein tau and other substrates. Altered PP2A activity has been implicated hi spinocerebellar ataxia 12, Alzheimer's disease (AD), and other tauopathies. Through a case-control study and a reporter assay, we investigated the association of PPP2R2B CAG repeat polymorphism with Taiwanese AD, essential tremor (ET), Parkinson's disease (PD), and schizophrenia and clarified the functional implication of this polymorphism. The distribution of the alleles was not significantly different between patients and controls, with 68.6-76.1% alleles at lengths of 10, 13, and 16 triplets. No expanded alleles were detected in either group. However, the frequency of the individuals carrying the short 5-, 6-, and 7-triplet alleles was notably higher in patients with AD (5/180 [2.8%], Fisher's exact test, P= 0.003; including 2 homozygotes) and ET (4/132 [3.0%], Fisher's exact test, P < 0.001) than in the controls (1/625 [0.2%]). The PPP2R2B transcriptional activity was significantly lower in the luciferase reporter constructs containing the (CAG)(5-7) allele than in those containing the common 10-, 13-, and 16-triplet alleles in both neuroblastoma and embryonic kidney cells. Therefore, our preliminary results suggest that the PPP2R2B gene CAG repeat polymorphism may be functional and may, in part, play a role in conferring susceptibility to AD and ET in Taiwan. (C) 2008 Wiley-Liss, Inc.

Genetic Risk Factors for Essential Tremor: A Review

TREMOR AND OTHER HYPERKINETIC MOVEMENTS

Authors: Siokas, Vasileios; Aloizou, Athina-Maria; Tsouris, Zisis; Liampas, Ioannis; Aslanidou, Paraskevi; Dastamani, Metaxia; Brotis, Alexandros G.; Bogdanos, Dimitrios P.; Hadjigeorgiou, Georgios M.; Dardiotis, Efthimios

Highlights In the current review, we thoroughly reviewed 74 identified articles regarding genes and genetic loci that confer susceptibility to ET. Over 50 genes/genetic loci have been examined for possible association with ET, but consistent results failed to be reported raising the need for collaborative multiethnic studies. Background: Essential tremor (ET) is a common movement disorder, which is mainly characterized by bilateral tremor (postural and/or kinetic) in the upper limbs, with other parts of the body possibly involved. While the pathophysiology of ET is still unclear, there is accumulating evidence indicating that genetic variability may be heavily involved in ET pathogenesis. This review focuses on the role of genetic risk factors in ET susceptibility. Methods: The PubMed database was searched for articles written in English, for studies with humans with ET, controls without ET, and genetic variants. The terms "essential tremor" and "polymorphism" (as free words) were used during search. We also performed meta-analyses for the most examined genetic variants. Results: Seventy four articles concerning LINGO1, LINGO2, LINGO4, SLC1A2, STK32B, PPARGC1A, CTNNA3, DRD3, ALAD, VDR, HMOX1, HMOX2, LRRK1, LRRK2, GBA, SNCA, MAPT, FUS, CYPsIL17A, IL1B, NOS1, ADH1B, TREM2, RIT2, HNMT, MTHFR, PPP2R2B, GSTP1, PON1, GABA receptors and GABA transporter, HS1BP3, ADH2, hSKCa3 and CACNL1A4 genes, and ETM genetic loci were included in the current review. Results from meta-analyses revealed a marginal association for the STK32B rs10937625 and a marginal trend for association (in sensitivity analysis) for the LINGO1 rs9652490, with ET. Discussion: Quite a few variants have been examined for their possible association with ET. LINGO1 rs9652490 and STK32B rs10937625 appear to influence, to some extent, ET susceptibility. However, the conflicting results and the lack of replication for many candidate genes raise the need for collaborative multiethnic studies.

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