Rabbit Anti-Human PPP2R1A (a.a. 239-589) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human; Mouse; Rat

Immunogen

Recombinant human PPP2R1A protein; Source: E. coli derived, PGEX-4T; Tag: GST; Domain: 239-589 aa of BC001537

Conjugate

Application Notes

WB: 1:1000-1:6000
IP: 0.5-4.0 μg for 1.0-3.0 mg of total protein lysate
IHC: 1:50-1:500
IF/ICC: 1:50-1:500

General Notes

This product (Catalog No. DPABH-12211) is a rabbit-derived polyclonal antibody raised against human PPP2R1A, targeting the amino acid region 239–589 of the protein. This antibody exhibits cross-reactivity with Human PPP2R1A from mouse and rat. It has been affinity purified by Protein A. PPP2R1A belongs to the phosphatase 2A regulatory subunit A family. PPP2R1A encodes the α-isoform of the scaffolding subunit of the serine/threonine protein phosphatase 2A (PP2A) holoenzyme. This tumour suppressor complex is involved in growth and survival pathways and PPP2R1A mutations in endometrial high-grade serous carcinomas are a frequent and potentially targetable feature of this disease(PMID: 21381030). The PPP2R1A gene has 86% identity with the PPP2R1B gene(PMID:7681822).
DPABH-12211 is suitable for use in Western blot (WB) (1:1,000–1:6,000), IP (0.5-4.0 μg for 1.0-3.0 mg of total protein lysate), IHC (1:50–1:500), IF/ICC (1:50–1:500) applications.
DPABH-12211 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform; PR65A; PP2A subunit A isoform R1-alpha; PP2A subunit A isoform PR65-alpha; Medium tumor antigen-associated 61 kDa protein

Entrez Gene ID

UniProt ID