Anti-POU5F1 monoclonal antibody, clone 452DU8.7.3

Name: Anti-POU5F1 monoclonal antibody, clone 452DU8.7.3
SKU: DCABY-1297
Rating: 5 (1 reviews)

Mouse anti-Human POU5F1 monoclonal antibody for WB

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COA

SDS

Datasheet

Summary

Specifications

Antibody Isotype

IgM

Clone

452DU8.7.3

Species Reactivity

Human; Mouse

Conjugate

Unconjugated

Applications

Application Notes

WB: 1:500-4000

Target

Alternative Names

POU5F1; OCT3; OCT4; OTF3; POU domain; class 5; transcription factor 1; Octamer-binding protein 3; Octamer-binding protein 4; Octamer-binding transcription factor 3

Entrez Gene ID

5460

UniProt ID

M1S623

Product Background

Antigen Description

This gene encodes a transcription factor containing a POUhomeodomain. This transcription factor plays a role in embryonicdevelopment, especially during early embryogenesis, and it isnecessary for embryonic stem cell pluripotency. A translocation ofthis gene with the Ewing's sarcoma gene, t(6; 22)(p21; q12), has beenlinked to tumor formation. Alternative splicing, as well as usageof alternative translation initiation codons, results in multipleisoforms, one of which initiates at a non-AUG (CUG) start codon.Related pseudogenes have been identified on chromosomes 1, 3, 8,10, and 12.

Pathway

Cardiac Progenitor Differentiation; HIF-2-alpha transcription factor network; SIDS Susceptibility Pathways; Wnt Signaling Pathway and Pluripotency

Citations