Specifications
Species Reactivity
Mouse; Rat; Human; Pig; Macaque
Immunogen
Synthetic peptide within Human Oct4 aa 1-14 (N terminal). The exact sequence is proprietary.Sequence: MAGHLASDFAFSPC Database link: P20263
Applications
Application Notes
IHC-Fr: 20μg/ml; WB: 1 - 2μg/ml; IP: 20μg/ml; Flow Cyt: IHC-P: 1/100;
Target
Alternative Names
POU5F1; POU class 5 homeobox 1; OCT3; OCT4; OTF3; OTF4; OTF-3; Oct-3; Oct-4; POU domain, class 5, transcription factor 1; octamer-binding protein 3; octamer-binding protein 4; POU domain transcription factor OCT4; octamer-binding transcription factor 3; P
Product Background
Antigen Description
Transcription factor that binds to the octamer motif (5-ATTTGCAT-3). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.
Pathway
Cardiac Progenitor Differentiation; HIF-2-alpha transcription factor network; POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation; Transcriptional regulation of pluripotent stem cells
Citations
Publication ()
Have you cited DPABH-15119 in a publication?
Let us know and earn a reward for your research.
COA
Loading ......
