Specifications
Immunogen
Recombinant fragment within Human Oct4 aa 1-182. The exact sequence is proprietary.Database link: Q01860
Applications
Application Notes
WB: 1/1000 - 1/10000; ICC/IF: 1/100 - 1/1000; Flow Cyt: 1/50; IP: 1/100 - 1/500.
Target
Alternative Names
POU5F1; POU class 5 homeobox 1; OTF3, POU domain class 5, transcription factor 1; POU domain, class 5, transcription factor 1; MGC22487; OCT3; Oct4; octamer-binding protein 3; octamer-binding protein 4; POU domain transcription factor OCT4; octamer-bindi
Product Background
Antigen Description
Transcription factor that binds to the octamer motif (5-ATTTGCAT-3). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.
Pathway
HIF-2-alpha transcription factor network, organism-specific biosystem; Wnt Signaling Pathway and Pluripotency, organism-specific biosystem;
Citations
Publication ()
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COA
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