General Notes
This product (Catalog No. DPABH-24790) is a rabbit-derived polyclonal antibody raised against human PON1. This antibody exhibits cross-reactivity with PON1 from mouse and rat. It has been affinity purified by Protein A. This gene encodes a member of the paraoxonase family of enzymes and exhibits lactonase and ester hydrolase activity. Following synthesis in the kidney and liver, the enzyme is secreted into the circulation, where it binds to high density lipoprotein (HDL) particles and hydrolyzes thiolactones and xenobiotics, including paraoxon, a metabolite of the insecticide parathion. Polymorphisms in this gene may be associated with coronary artery disease and diabetic retinopathy. The gene is found in a cluster of three related paraoxonase genes on chromosome 7.
DPABH-24790 is suitable for use in Western blot (WB) (1:1,000–1:5,000), IHC (1:50–1:200) applications.
DPABH-24790 is supplied as a liquid formulation in pH7.4 PBS, 0.05% sodium azide, 40% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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