Anti-PON1 monoclonal antibody, clone FQS3903

Antibody Isotype

IgG

Clone

FQS3903

Species Reactivity

Human

Immunogen

Synthetic peptide corresponding to residues near the N terminus of Human PON1.

Conjugate

Application Notes

IHC-P: 1/100 - 1/250; IP: 1/10 - 1/100; WB: 1/1000 - 1/10000.

Alternative Names

PON1; paraoxonase 1; PON; serum paraoxonase/arylesterase 1; ESA; esterase A; A esterase 1; A-esterase 1; Aromatic esterase 1; Arylesterase B type; ESA; Esterase A; K 45; K-45; MVCD5; Paraoxonase 1; Paraoxonase; Paraoxonase B type; Paraoxonase1; PON 1; PON

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.

Pathway

Metabolic pathways, organism-specific biosystem;