Perilipin is an intracellular neutral lipid droplet protein that is hormonally regulated. This protein is localized exclusively to the surface of lipid droplets. In response to lypotic stimuli, perilipin is phosphorylated by protein kinase A. Once activated, perilipin has inhibitory affects upon hormone-sensitive lipase (HSL), a protein that mediates the hydrolysis of triacylglycerol, the major form of stored energy in the body. Perilipin expression is limited to adipocytes and steroidogenic cells. There are currently two known isoforms, Perilipin A and B. Both of these proteins are encoded by a single-copy gene and are the result of differential splicing events.
Pathway
Adipogenesis; Lipid digestion, mobilization, and transport; Metabolism of lipids and lipoproteins; PPAR signaling pathway
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Zhang, HL; Fan, HJ; et al. Molecular cloning of the perilipin gene and its association with carcass and fat traits in Chinese ducks. GENETICS AND MOLECULAR RESEARCH 12:1582-1592(2013).
Rimbach, G; Minihane, AM; et al. Nutrition Society Silver Medal Lecture Nutrigenetics and personalised nutrition: how far have we progressed and are we likely to get there?. PROCEEDINGS OF THE NUTRITION SOCIETY 68:162-172(2009).
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