Anti-PLIN1 (aa 1-20; cf) polyclonal antibody

Species Reactivity

Human

Immunogen

Duplicated N-terminus of perilipin (aa 1-20; cf. Greenberg et al. 1992, JBC 266, 11341-11346)

Conjugate

Application Notes

1:100 - 200 for immunohistochemistry; 1:2000 for immunoblotting (Western (ECL))

Alternative Names

PLIN1; perilipin 1; PERI; PLIN; FPLD4; perilipin; Perilipin-1; Lipid droplet-associated protein; perilipin-1; lipid droplet-associated protein; OTTHUMP000001946892; OTTHUMP00000228582

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene coats lipid storage droplets in adipocytes, thereby protecting them until they can be broken down by hormone-sensitive lipase. The encoded protein is the major cAMP-dependent protein kinase substrate in adipocytes and, when unphosphorylated, may play a role in the inhibition of lipolysis. Alternatively spliced transcript variants varying in the 5" UTR, but encoding the same protein, have been found for this gene.

Pathway

Adipogenesis; Developmental Biology; Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis; Lipid digestion, mobilization, and transport; Metabolism of lipids and lipoproteins; PPAR signaling pathway; Transcriptional Regulation of White Adipocyte Differentiation