Anti-PAFAH1B1 monoclonal antibody, clone FQS4446(3)

Antibody Isotype

IgG

Clone

FQS4446(3)

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide corresponding to residues in Human LIS1.

Conjugate

Application Notes

IP: 1/10 - 1/100; WB: 1/1000 - 1/10000; Flow Cyt: 1/1000 - 1/10000.

Alternative Names

PAFAH1B1; platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa); MDCR, MDS, Miller Dieker syndrome chromosome region , platelet activating factor acetylhydrolase, isoform Ib, alpha subunit (45kD) , platelet activating factor acety

Entrez Gene ID

UniProt ID

Antigen Description

Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing.

Pathway

Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Centrosome maturation, organism-specific biosystem; DNA Replication, organism-specific biosystem; Ether lipid metabolism, organism-specific biosystem; Ether lipid metabolism, conserved biosystem; G2/M Transition, organism-specific biosystem;