Rabbit Anti-Human PAFAH1B1 (internal) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human; Mouse; Rat

Immunogen

Synthetic peptide corresponding to a region derived from internal residues of human platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)

Conjugate

Application Notes

IHC: 1:25-1:100

General Notes

This product (Catalog No. DPABH-15347) is a rabbit-derived IgG polyclonal antibody raised against human PAFAH1B1. This antibody exhibits cross-reactivity with PAFAH1B1 from mouse and rat. It has been affinity purified by protein A. This locus was identified as encoding a gene that when mutated or lost caused the lissencephaly associated with Miller-Dieker lissencephaly syndrome. This gene encodes the non-catalytic alpha subunit of the intracellular Ib isoform of platelet-activating factor acteylhydrolase, a heterotrimeric enzyme that specifically catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist: one composed of multiple subunits, the other, a single subunit. In addition, a single-subunit isoform of this enzyme is found in serum.
DPABH-15347 is suitable for use in IHC (1:25–1:100) application.
DPABH-15347 is supplied as a liquid formulation in pH7.4 PBS, 0.05% sodium azide, 40% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

MDS; LIS1; LIS2; MDCR; PAFAH

Entrez Gene ID

UniProt ID