Anti-PA2G4 monoclonal antibody, clone FQS25670(C)

Antibody Isotype

IgG

Clone

FQS25670(C)

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human EBP1 aa 300 to the C-terminus. The exact sequence is proprietary.Database link: Q9UQ80

Conjugate

Application Notes

IHC-P: 1/50 - 1/100; WB: 1/10000 - 1/50000; IP: 1/30; ICC/IF: 1/100; Flow Cyt: 1/20.

Alternative Names

PA2G4; proliferation-associated 2G4, 38kDa; proliferation associated 2G4, 38kD; proliferation-associated protein 2G4; erbB3-binding protein 1; ErbB-3 binding protein 1; ErbB3-binding protein Ebp1; cell cycle protein p38-2G4 homolog; EBP1; HG4-1; p38-2G4;

Entrez Gene ID

UniProt ID

Antigen Description

May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site).

Pathway

Androgen Receptor Signaling Pathway, organism-specific biosystem; Coregulation of Androgen receptor activity, organism-specific biosystem;