Human PA2G4 peptide

Specificity

Expressed in several cell lines tested, including primary and transformed cell lines.

Nature

Synthetic

Tag/Conjugate

Unconjugated

Format

Liquid

Preservative

None

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.

Gene ID

5036

UniProt ID

Q9UQ80

Antigen Description

This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified. [provided by RefSeq, Jul 2008]

Function

DNA binding; poly(A) RNA binding; protein binding; sequence-specific DNA binding transcription factor activity; ubiquitin protein ligase binding;

Synonyms

PA2G4; proliferation-associated 2G4, 38kDa; EBP1; HG4-1; p38-2G4; proliferation-associated protein 2G4; erbB3-binding protein 1; ErbB-3 binding protein 1; ErbB3-binding protein Ebp1; cell cycle protein p38-2G4 homolog;