Anti-PA2G4 monoclonal antibody, clone 2E4

Antibody Isotype

IgG1

Clone

2E4

Species Reactivity

Human

Immunogen

Recombinant full length Human EBP1 produced in HEK293T cells (NP_006182).

Conjugate

Application Notes

WB: 1/2000;

Alternative Names

PA2G4; proliferation-associated 2G4, 38kDa; proliferation associated 2G4, 38kD; proliferation-associated protein 2G4; erbB3-binding protein 1; ErbB-3 binding protein 1; ErbB3-binding protein Ebp1; cell cycle protein p38-2G4 homolog; EBP1; HG4-1; p38-2G4;

Entrez Gene ID

UniProt ID

Antigen Description

May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site).

Pathway

Androgen Receptor Signaling Pathway, organism-specific biosystem; Coregulation of Androgen receptor activity, organism-specific biosystem;