Specifications
Species Reactivity
Human, Bovine, Chimpanzee, Dog, Horse, Mouse, Pig, Rabbit, Rat, Rhesus monkey
Immunogen
Synthetic peptide, PLPDCCRQKTCSC, corresponding to amino acids 2-14 of human orexin A conjugated to KLH.
Applications
Application Notes
ELISA: 1/20 - 1/100;
Target
Alternative Names
HCRT; hypocretin (orexin) neuropeptide precursor; OX; PPOX; NRCLP1; orexin; prepro-orexin; OREXIN A;
Product Background
Pathway
Class A/1 (Rhodopsin-like receptors); Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD); Disease; G alpha (q) signalling events; GPCR downstream signaling; GPCR ligand binding; Gastrin-CREB signalling pathway via PKC and MAPK; Metabolic disorders of biological oxidation enzymes;
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.
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Citations
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Zhang, JH; Sampogna, S; et al. Co-localization of hypocretin-1 and hypocretin-2 in the cat hypothalamus and brainstem. PEPTIDES 23:1479-1483(2002).
Cvetkovic-Lopes, V; Eggermann, E; et al. Rat Hypocretin/Orexin Neurons Are Maintained in a Depolarized State by TRPC Channels. PLOS ONE 5:-(2010).
COA
Certificate of Analysis
