Anti-Natural Killer Cell Activation Structures monoclonal antibody (DMAB12238)

Mouse anti-Rat Natural Killer Cell Activation Structures monoclonal antibody for IHC, IP, FC Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
BOL72
Species Reactivity
Rat
Immunogen
Native purified from IL-2-activated cultured NK cells of Wag rats.
Conjugate
Unconjugated

Target


Alternative Names
Natural killer cells; NK cells; Mouse Anti-Natural Killer Cell Activation Structures Monoclonal Antibody; Anti-Natural Killer Cell Activation Structures Monoclonal Antibody; Natural Killer Cell Activation Structures Monoclonal Antibody Mouse Anti-Natural

Product Background


Antigen Description
Natural killer cells (or NK cells) are a type of cytotoxic lymphocyte critical to the innate immune system. The role NK cells play is analogous to that of cytotoxic T cells in the vertebrate adaptive immune response. NK cells provide rapid responses to virally infected cells and respond to tumor formation, acting at around4days after infection. Typically immune cells detect MHC presented on infected cell surfaces, triggering cytokine release causing lysis or apoptosis. NK cells are unique, however, as they have the ability to recognise stressed cells in the absence of antibodies and MHC, allowing for a much faster immune reaction. They were named "natural killers" because of the initial notion that they do not require activation in order to kill cells that are missing "self" markers of major histocompatibility complex (MHC) class2.

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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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