Anti-MKNK1 (full length) polyclonal antibody

Species Reactivity

Human

Immunogen

MKNK1 (AAH02755.1, 1 a.a. ~ 465 a.a) full-length recombinant protein with GST tag. The sequence is MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQRNKNILELIEFFEDDTRF YLVFEKLQGGSILAHIQKQKHFNEREASRVVRGVAAALDFLHTKDKVSLCHLGWSAMAPS GLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMK LNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPP FVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAK QRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLF

Conjugate

Alternative Names

MKNK1; MAP kinase interacting serine/threonine kinase 1; MNK1; MAP kinase-interacting serine/threonine-protein kinase 1; MAPK signal-integrating kinase 1; MAP kinase signal-integrating kinase 1;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene.

Pathway

Disease; Insulin signaling pathway; Negative regulation of FGFR signaling; Signaling by FGFR