Anti-MFN2 (aa 38-55) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse; Rat; Human; Duck; Pygoscelis adeliae

Immunogen

Synthetic peptide: KINGIFEQLGAYIQESAT with C-terminal added cysteine, conjugated to KLH, corresponding to N terminal amino acids 38-55 of Human Mitofusin 2

Conjugate

Application Notes

WB: 0.5 - 1 μg/ml; IP: 5-10μg; ICC/IF: 20 - 30 μg/ml;

Alternative Names

MFN2; mitofusin 2; HSG; MARF; CMT2A; CPRP1; CMT2A2; mitofusin-2; hyperplasia suppressor; transmembrane GTPase MFN2; mitochondrial assembly regulatory factor;

Entrez Gene ID

UniProt ID

Antigen Description

Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. Plays an important role in the regulation of vascular smooth muscle cell proliferation.

Pathway

Factors involved in megakaryocyte development and platelet production;