Rabbit Anti-Human MFN2 (a.a. 381-566) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human; Mouse; Rat

Immunogen

Recombinant human MFN2 protein; Source: E. coli derived, PGEX-4T; Tag: GST; Domain: 381-566 aa of BC017061

Conjugate

Application Notes

WB: 1:500-1:2000
IHC: 1:50-1:500

General Notes

This product (Catalog No. DPABH-20923) is a rabbit-derived polyclonal antibody raised against human MFN2, targeting the amino acid region 381–566 of the protein. This antibody exhibits cross-reactivity with Human MFN2 from mouse and rat. It has been affinity purified by Protein A. MFN2, also named as CPRP1 and KIAA0214, belongs to the mitofusin family. It is an Essential transmembrane GTPase, which mediates mitochondrial fusion. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression of MFN2 induces the formation of mitochondrial networks. It plays an important role in the regulation of vascular smooth muscle cell proliferation. Defects in MFN2 are the cause of Charcot-Marie-Tooth disease type 2A2 (CMT2A2). Defects in MFN2 are the cause of Charcot-Marie-Tooth disease type 6 (CMT6). Ubiquitinated forms of Mfn2 (mono- and polyubiquitinated) are present during mitophagy.
DPABH-20923 is suitable for use in Western blot (WB) (1:500–1:2,000), IHC (1:50–1:500) applications.
DPABH-20923 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

CMT2A; CMT2A2; CPRP1; HSG; KIAA0214; MARF; MFN2; mitofusin 2; Transmembrane GTPase MFN2

Entrez Gene ID

UniProt ID