Anti-MFN2 monoclonal antibody

Antibody Isotype

IgG2a

Species Reactivity

Mouse; Rat; Cow; Human; Cynomolgus

Immunogen

Recombinant fragment: FKRQFVEHAS EKLQLVISYT GSNCSHQVQQ ELSGTFAHLC QQVDVTRENL EQEIAAMNKK IEVLDSLQSK AKLLRNKAGW LDSELNMFTH QYLQPSR, corresponding to amino acids 661-758 of Human Mitofusin 2

Conjugate

Application Notes

WB: 1 - 5 μg/ml; IHC-P: 3 μg/ml; IP: 5 μg/mg of lysate; Flow Cyt: 1μg/10⁶ cells;

Alternative Names

MFN2; mitofusin 2; mitofusin-2; CMT2A2; CPRP1; KIAA0214; MARF; hyperplasia suppressor; transmembrane GTPase MFN2; mitochondrial assembly regulatory factor; HSG; CMT2A;

Entrez Gene ID

UniProt ID

Antigen Description

Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. Plays an important role in the regulation of vascular smooth muscle cell proliferation.

Pathway

Factors involved in megakaryocyte development and platelet production, organism-specific biosystem; Hemostasis, organism-specific biosystem;