Anti-MFN2 (aa 661-757) polyclonal antibody

Species Reactivity

Human

Immunogen

MFN2 (NP_055689, 661 a.a. ~ 757 a.a) partial recombinant protein with GST tag. The sequence is FKRQFVEHASEKLQLVISYTGSNCSHQVQQELSGTFAHLCQQVDVTRENLEQEIAAMNKK IEVLDSLQSKAKLLRNKAGWLDSELNMFTHQYLQPSR

Conjugate

Alternative Names

MFN2; mitofusin 2; HSG; MARF; CMT2A; CPRP1; CMT2A2; mitofusin-2; hyperplasia suppressor; transmembrane GTPase MFN2; mitochondrial assembly regulatory factor;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified.

Pathway

Factors involved in megakaryocyte development and platelet production;