DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). However, unlike the other family members, MBD3 is not capable of binding to methylated DNA. The predicted MBD3 protein shares 71% and 94% identity with MBD2 (isoform 1) and mouse Mbd3. MBD3 is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. MBD3 mediates the association of metastasis-associated protein 2 (MTA2) with the core histone deacetylase complex.
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Lorincz, MC; Schubeler, D; et al. Methylation-mediated proviral silencing is associated with MeCP2 recruitment and localized histone H3 deacetylation. MOLECULAR AND CELLULAR BIOLOGY 21:7913-7922(2001).
Sakai, H; Urano, T; et al. MBD3 and HDAC1, two components of the NuRD complex, are localized at aurora-A-positive centrosomes in M phase. JOURNAL OF BIOLOGICAL CHEMISTRY 277:48714-48723(2002).
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