Does not bind DNA by itself. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing.
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Uno, T; Nomura, Y; et al. Expression, purification and characterization of methyl DNA binding protein from Bombyx mori. JOURNAL OF INSECT SCIENCE 5:-(2005).
Lorincz, MC; Schubeler, D; et al. Methylation-mediated proviral silencing is associated with MeCP2 recruitment and localized histone H3 deacetylation. MOLECULAR AND CELLULAR BIOLOGY 21:7913-7922(2001).
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