Magic™ Anti-MAPK14 (Phospho T180) polyclonal antibody [Biotin]

Antibody Isotype

IgY

Species Reactivity

Human

Immunogen

Synthetic phosphopeptide corresponding to amino acids of MAPK14 The sequence is HTDDEM(pT)GYVATR

Conjugate

Alternative Names

MAPK14; mitogen-activated protein kinase 14; RK; p38; CSBP; EXIP; Mxi2; CSBP1; CSBP2; CSPB1; PRKM14; PRKM15; SAPK2A; p38ALPHA; MAP kinase 14; p38alpha Exip; p38 MAP kinase; MAP kinase Mxi2; MAP kinase p38 alpha; CSAID-binding protein; Csaids binding prote

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Pathway

ADP signalling through P2Y purinoceptor 1; ATF-2 transcription factor network; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; Adrenergic signaling in cardiomyocytes