Mouse Anti-MAPK14 Hybridoma [10G13] (CSC-LS02)

Regulatory status: For research use only, not for use in diagnostic procedures.

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General Information


Immunogen
Full-length recombinant protein expressed in E. Coli cells. The purity was determined to be >90% by densitometry. Approx. MW 38kDa.
Isotype
IgG1
Fusion Species
Mouse X Mouse Hybridoma
Myeloma
SP2/0 Mus musculus
Clone
10G13
Cell Line Description
2 x 10^6 – 2 x 10^7 cells/ml in freezing media. 10% dimethylsulfoxide (DMSO) and 90% Fetal Bovine Serum (FBS). Product is frozen.
Tested for cross reactivity with closely related human kinases. No cross reactivity detected.
Format
Frozen
Morphology
lymphoblast
Growth Properties
suspension

Culture Method


Complete Growth Medium
DMEM +5-10% FBS
Storage
Store in liquid nitrogen.

Target


Introduction
P38α(SAPK2A) encoded by the MAPK14 gene is a member of the P38 MAPK family which are activated by various environmental stresses and proinflammatory cytokines. The activation of p38 requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of p38 include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response.

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