Antigen Description
p38 MAPK cascade regulates a variety of cellular responses to stress, inflammation and other signals. p38 MAPK is relatively inactive in the non-phosphorylated form and becomes rapidly activated by dual phosphorylation of a Thr-Gly-Tyr motifs. There are four isoforms of p38 MAPK, CSBP1, CSBP2, CSPB1, and MXI2 , which differ in their tissue expression and affinity for upstream activators and downstream effectors. When cells are exposed to tumor necrosis factor-alpha, interleukin-1, heat shock, or other activating stimuli, activation of MAPK kinase-3 and -6 occurs by phosphorylation. Activated MAPK kinase-3/6 phosphorylate each residue of Thr180 and Tyr182 in p38 MAPK. Phospho-p38 MAPK activates ATF-2, CHOP-1, MEF-2 and other transcription factors through phosphorylation.
Pathway
ADP signalling through P2Y purinoceptor 1; ATF-2 transcription factor network; Activated TLR4 signalling; Activation of the AP-1 family of transcription factors; Amyotrophic lateral sclerosis (ALS); Angiopoietin receptor Tie2-mediated signaling; Atypical NF-kappaB pathway; B Cell Receptor Signaling Pathway
COA
Publication 
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