Anti-TAB3 monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human MAP3K7IP3 is used for rabbit immunization.

Conjugate

Alternative Names

TAB3; TGF-beta activated kinase 1/MAP3K7 binding protein 3; NAP1; MAP3K7IP3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3; TAB-3; TAK1-binding protein 3; NFkB activating protein 1; NF-kappa-B-activating protein 1; TGF-beta-activated kinase 1-b

Entrez Gene ID

UniProt ID

Antigen Description

The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Pathway

Activated TLR4 signalling; Cytokine Signaling in Immune system; FCERI mediated NF-kB activation; Fc epsilon receptor (FCERI) signaling; IRAK2 mediated activation of TAK1 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; Immune System; Innate Immune System; Interleukin-1 signaling; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; MAP kinase activation in TLR cascade;