Synthetic peptide: C-HSPDDNRMNRN (with a Cysteine residue linker), corresponding to internal sequence amino acids 59-69 of Human TAB3 (NP_690000.2).
Conjugate
Unconjugated
Applications
Application Notes
IHC-P: 3.75 μg/ml.
Target
Alternative Names
TAB3; TGF-beta activated kinase 1/MAP3K7 binding protein 3; MAP3K7IP3, mitogen activated protein kinase kinase kinase 7 interacting protein 3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3; TAK1 binding protein 3; TAB-3; TAK1-binding protein 3;
Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor.
Pathway
Activated TLR4 signalling; Cytokine Signaling in Immune system; IRAK2 mediated activation of TAK1 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; Immune System; Innate Immune System; Interleukin-1 signaling
Citations
Publication ()
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