The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Function
protein binding; zinc ion binding
Synonyms
TAB3; TGF-beta activated kinase 1/MAP3K7 binding protein 3; NAP1; MAP3K7IP3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3; TAB-3; TAK1-binding protein 3; NFkB activating protein 1; NF-kappa-B-activating protein 1; TGF-beta-activated kinase 1-binding protein 3; mitogen-activated protein kinase kinase kinase 7 interacting protein 3
Citations
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