Human TAB3 blocking peptide

Product Overview

Blocking/Immunizing peptide for anti-MAP3K7IP3 (aa 274 to 285) antibody

Target

MAP3K7IP3 (aa 274 to 285)

Nature

Synthetic

Tag/Conjugate

Unconjugated

Application Notes

For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.

Format

Lyophilized powder

Preservative

None

Storage

Shipped at ambient temperature, store at -20°C.

Entrez Gene ID

Antigen Description

The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Function

metal ion binding; protein binding; zinc ion binding;

Synonyms

TAB3; TGF-beta activated kinase 1/MAP3K7 binding protein 3; MAP3K7IP3, mitogen activated protein kinase kinase kinase 7 interacting protein 3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3; TAK1 binding protein 3; TAB-3; TAK1-binding protein 3; NFkB activating protein 1; NF-kappa-B-activating protein 1; TGF-beta-activated kinase 1-binding protein 3; mitogen-activated protein kinase kinase kinase 7 interacting protein 3; NAP1; MAP3K7IP3; MGC45404;