Anti-LNX1 (aa 19-118) polyclonal antibody

Species Reactivity

Human

Immunogen

LNX1 (NP_116011, 19 a.a. ~ 118 a.a) partial recombinant protein with GST tag. The sequence is DNVGNLHFLYSELCKGAFHYGLTKDRKRRSQDGCPDGCASLTATAPSPEVSAAATISLMT DEPGLDNPAYVSSAEDGQPAISPVDSGRSNRTRARPFERS

Conjugate

Alternative Names

LNX1; ligand of numb-protein X 1, E3 ubiquitin protein ligase; LNX; MPDZ; PDZRN2; E3 ubiquitin-protein ligase LNX; numb-binding protein 1; PDZ domain-containing ring finger protein 2; multi-PDZ-domain-containing protein, E3 ubiquitin-protein ligase LNX;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a membrane-bound protein that is involved in signal transduction and protein interactions. The encoded product is an E3 ubiquitin-protein ligase, which mediates ubiquitination and subsequent proteasomal degradation of proteins containing phosphotyrosine binding (PTB) domains. This protein may play an important role in tumorogenesis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene, which is located on chromosome 17, has been identified for this gene.

Pathway

Notch signaling pathway;