Anti-LNX1 monoclonal antibody

Antibody Isotype

IgG2a

Species Reactivity

Human

Immunogen

Recombinant fragment: DNVGNLHFLY SELCKGAFHY GLTKDRKRRS QDGCPDGCAS LTATAPSPEV SAAATISLMT DEPGLDNPAY VSSAEDGQPA ISPVDSGRSN RTRARPFERS, corresponding to amino acids 19-119 of human Lnx1 with a tag.

Conjugate

Alternative Names

LNX1; ligand of numb-protein X 1, E3 ubiquitin protein ligase; ligand of numb protein X , ligand of numb protein X 1 , LNX; E3 ubiquitin-protein ligase LNX; MPDZ; PDZRN2; numb-binding protein 1; PDZ domain-containing ring finger protein 2; multi-PDZ-doma

Entrez Gene ID

UniProt ID

Antigen Description

Lnx1 is a membrane-bound protein that is involved in signal transduction and protein interactions. Lnx1 is an E3 Ubiquitin ligase protein that mediates ubiquitination and subsequent proteasomal degradation of proteins containing phosphotyrosine binding (PTB) domains. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Lnx1 mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65.

Pathway

Notch signaling pathway, organism-specific biosystem;