Anti-ITGA2 monoclonal antibody, clone INb3 Functional Grade

Antibody Isotype

IgG

Clone

INb3

Species Reactivity

Mouse

Immunogen

The details of the immunogen for this antibody are not available. corresponding to CD49b.

Conjugate

Application Notes

Flow Cyt: 0.5μg/10⁶ cells.

Alternative Names

ITGA2; integrin alpha 2; integrin alpha-2; GPIa; collagen receptor; VLA-2 subunit alpha; VLA-2 receptor, alpha 2 subunit; CD49 antigen-like family member B; platelet membrane glycoprotein Ia; DX5; CD49B;

Entrez Gene ID

UniProt ID

Antigen Description

Human CD49b is an integrin alpha 2 subunit that forms a heterodimer with beta 1 integrin and functions as an adhesion molecule. CD49b is a 160 kDa glycoprotein that noncovalently associates with the 130 kDa integrin beta 1 subunit (CD29) to form glycoprotein Ia/IIa (when expressed on platelets), and very late (activation) antigen 2 (VLA2) when found on T cells. CD49b is expressed by platelets, approximately 50% of monocytes, long term cultivated T cells and most adherent cell lines. Integrin alpha 2/beta 1 is a receptor for laminin, collagen, collagen C propeptides, fibronectin and E cadherin. It recognizes the proline hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.

Pathway

Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem; Dilated cardiomyopathy, organism-specific biosystem; Dilated cardiomyopathy, conserved biosystem; ECM-receptor interaction, organism-specific biosystem; ECM-receptor interaction, conserved biosystem; Focal Adhesion, organism-specific biosystem;