Anti-ITGA2 monoclonal antibody, clone 27C5

Antibody Isotype

IgG1

Clone

27C5

Species Reactivity

Human

Immunogen

Purified human beta 1 preparation from HT1080 fibrosarcoma cell extract.

Conjugate

Application Notes

ICC/IF: 1 μg/ml; IP: 25 - 50 μg/ml; Flow Cyt: 0.1μg/10⁶ cells; ELISA: 10 μg/ml; IHC-Fr: 30 - 40 μg/ml.

Alternative Names

ITGA2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); CD49B; integrin alpha-2; CD49b; integrin alpha 2; collagen receptor; VLA-2 subunit alpha; platelet antigen Br; platelet glycoprotein Ia; platelet glycoprotein GPIa; CD49 antigen-like fam

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants.

Pathway

Arf6 trafficking events, organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem; Axon guidance, organism-specific biosystem; CHL1 interactions, organism-specific biosystem; CXCR4-mediated signaling events, organism-specific biosystem; Developmental Biology, organism-specific biosystem;