Specifications
Immunogen
Integrin alpha 2
Target
Alternative Names
ITGA2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); CD49B; integrin alpha-2; CD49b; integrin alpha 2; collagen receptor; VLA-2 subunit alpha; platelet antigen Br; platelet glycoprotein Ia; platelet glycoprotein GPIa; CD49 antigen-like fam
Product Background
Antigen Description
Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.
Pathway
Arf6 trafficking events, organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem; Axon guidance, organism-specific biosystem; CHL1 interactions, organism-specific biosystem; CXCR4-mediated signaling events, organism-specific biosystem; Developmental Biology, organism-specific biosystem;
Citations
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Kunicki, TJ; Williams, SA; et al. Mean Platelet Volume and Integrin Alleles Correlate With Levels of Integrins alpha(IIb)beta(3) and alpha(2)beta(1) in Acute Coronary Syndrome Patients and Normal Subjects. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 32:147-U337(2012).
Holtkotter, O; Nieswandt, B; et al. Integrin alpha(2)-deficient mice develop normally, are fertile, but display partially defective platelet interaction with collagen. JOURNAL OF BIOLOGICAL CHEMISTRY 277:10789-10794(2002).
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