Anti-HA monoclonal antibody, clone 3D21I3

Name: Anti-HA monoclonal antibody, clone 3D21I3
SKU: CAB-791MS
Rating: 5 (1 reviews)

Mouse Anti-IAV HA monoclonal antibody for WB, ELISA

Write a review

COA

SDS

Datasheet

Summary

Specifications

Antibody Isotype

IgG1

Clone

3D21I3

Species Reactivity

IAV

Immunogen

Recombinant H1N1 HA protein

Conjugate

Unconjugated

Target

Alternative Names

Influenza A Hemagglutinin; Influenza A; H1N1; Group V ((-)ssRNA); Orthomyxoviridae; S-OIV A Hemagglutinin; Swine flu H1

Product Background

Antigen Description

Influenza (flu) is a respiratory infection in mammals and birds. This virus is divided into three main types (A, B and C). Influenza A is found in a wide variety of bird and mammal species. Influenza B is largely confined to humans and is an important cause of morbidity. Influenza C infects humans, dogs and pigs, sometimes causing both severe illness and local epidemics. Influenza A is further divided into subtypes based on differences in the membrane proteins hemagglutinin (HA) and neuraminidase (NA). The notation HhNn is used to refer to the subtype comprising the hth discovered HA protein and the nth discovered NA protein. The HA is a trimer with a receptor binding pocket on the globular head of each monomer. Subtypes are further divided into strains. Each genetically distinct virus isolate is usually considered to be a separate strain.
The H1N1 viral strain ( A/California/04/2009 ) implicated in the 2009 flu pandemic among humans is often called "swine flu" because initial testing showed many of the genes in the virus were similar to influenza viruses normally occurring in North American swine. Two children in southern California were infected with H1N1 swine flu. The isolates are similar and have an unusual constellation of genes. The lack of contact between the two children, as well as a lack of contact with swine, suggests the virus is spreading human to human. The presence of swine H1N1 in humans raises concerns of recombination with H1N1 seasonal flu. Moreover, the 1918 pandemic strain was a recombinant between human H1N1 and swine H1N1. The likely ability of this swine H1N1 to transmit efficiently in humans is cause for concern. The HA, NA, and MP sequences of A/California/04/2009 have been placed on deposit at GISAID.

Citations

Have you cited CAB-791MS in a publication? Let us know and earn a reward for your research.

Documents

pdf COA

pdf SDS

pdf Datasheet

QA & Reviews

Customer Reviews

References

Elimination Pathways of Fusion Protein and Peptide Drugs

BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY

Authors: Khodadoust, Ali; Aghamollaei, Hossein; Latifi, Ali Mohammad; Hasanpour, Kazem; Kamali, Mahdi; Tebyanian, Hamid; Farnoosh, Gholamreza

Abstract

Fusion proteins ha\ e been kno n as an interesting subject for scientific researches in improving properties or making a new function b synergistically incorporating tiro protein domains into one complex. Fusion proteins are created by ligation of tA o or more protein domains in a single polypeptide with functional properties. Impro ement of therapeutic function is one of the main goals for developing these products. Elimination from the body is one of the most important points that should be considered in the design and production of fusion proteins. This roiew describes some of the most important excretion/elimination pathways of fusion peptide and protein drugs as well as serious elimination challenges in the do elopment and manufacturing of fusion proteins.

Nature Based Solutions for Climate Adaptation - Paying Farmers for Flood Control

ECOLOGICAL ECONOMICS

Authors: Zandersen, Marianne; Oddershede, Jakob Stoktoft; Pedersen, Anders Branth; Nielsen, Helle Orsted; Termansen, Mette

Abstract

Climate change is expected to lead to more frequent and severe fluvial flood events in Northern Europe. Nature Based Solutions are increasingly recognised as a natural insurance against flood risks in vulnerable areas. This requires collaboration at landscape scale between providers and beneficiaries of flood control. In particular, mechanisms to incentivise owners of land could potentially offer cost-effective ways to reduce damage to urban infrastructure. We conduct a choice experiment among farmers located in the vicinity of a river to assess their willingness to accept a contract that would allow a local Danish municipality to periodically flood farmland to reduce urban flood risks. Results indicate that farmers on average are hesitant about entering into abatement contracts, especially if they have prior experience of crop losses due to extreme weather events. If they were to agree on a contract they would prefer a separate compensation for lost crops; a collective negotiation and higher rather than lower yearly payments. Surprisingly, data did not show a significant preference for or against a requirement to grow flood resistant crops. The results suggest that a contract with a separate damage compensation and based on individual negotiation would on average require an annual payment of 290Euro/ha for farmers with no prior experience of crop losses and 469Euro/ha for farmers who have experienced crop losses. The paper discusses the potentials and limitations of landscape scale Nature Based Solutions for climate adaptation.